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Nebivolol reduces the activity of renin, reduces the heart rate during exercise and at rest, and reduces the oxygen demand of the heart muscle. It also has antianginal, antiarrhythmic, antihypertensive effects. A dose adjustment and safety monitoring oral nebivolol 10 mg may be required in such cases. Symptoms like cold and numb hands and feet, muscle pain and weakness, severe headache etc. should be reported to the doctor. This medicine is not recommended for use during pregnancy unless absolutely necessary.